80 The impact of sex and physical performance on long-term mortality in older patients with myocardial infarction

Abstract Aims To investigate the prognostic role of sex and physical performance on long-term mortality in older adults hospitalized for acute coronary syndrome (ACS). Methods results The analysis is based (≥70 years) ACS patients included FRASER, HULK, LONGEVO SCA prospective studies. Physical was assessed with Short Performance Battery (SPPB). primary outcome all-cause mortality. study 1388 patients, 441 (32%) were women. At presentation, women more compromised than men. After a median follow-up 998 (730–1168) days, death occurred 334 (24.1%) patients. univariate analysis, female related to increased risk death. adjustments confounding factors, no longer associated Women showed poor compared men (P < 0.001). SPPB values emerged as independent predictor Including clinical features multivariable model, we observed paradigm shift that becomes protective factor (HR: 0.73, 95% CI: 0.56–0.96). Sex significant interaction = 0.03). For lower (poor performance), sex-related changes not recorded, while higher (preserved better survival. Conclusions Two key findings from present real-life cohort patients: (i) strongly influences (ii) preserved have